Laboratory and Field Experimental Study of Underwater Inflatable Co-prime Sonar Array (UICSA)

This paper discusses the design and initial testing of a novel hydrophone array system dubbed the Underwater Inflatable Co-prime Sonar Array (UICSA). The UICSA will be a crucial component of an underwater deployable sensing network that can be rapidly deployed using compact autonomous underwater vehicles (AUVs). The UICSA initially is packed in a compact container to fit the payload space of an AUV. After deployment, the UICSA expands to its predetermined full length to acquire sensing data for source localization.  More specifically, the mechanical compression of the UICSA is achieved through a non-rigid array support structure, which consists of flexible inflatable segments between adjoining hydrophones that are folded in order to package the UICSA for deployment. The system exploits compression in hydrophone layouts by utilizing a sparse array configuration, namely the co-prime array since it requires fewer hydrophones than a uniform linear array of the same length to estimate a given number of sources. With two-way compression, the storage, handling, and transportation of the compactly designed UICSA is convenient, particularly for the AUVs with limited payload space. The deployment concept and process are discussed, as well as the various UICSA designs of different support structures are described. A comparison of the various mechanical designs is presented and a novel hybrid-based expansion prototype is documented in detail. Laboratory study results of the UICSA prototype are presented that include water-swollen material tests in a pressurized environment and water tank validation of the inflation process. The UICSA prototype also has been deployed in the Harbor Branch channel to validate the performance, the related field test details and source localization results

Sudden Unexpected Deaths and Vaccinations during the First Two Years of Life in Italy: A Case Series Study

Background The signal of an association between vaccination in the second year of life with a hexavalent vaccine and sudden unexpected deaths (SUD) in the two days following vaccination was reported in Germany in 2003. A study to establish whether the immunisation with hexavalent vaccines increased the short term risk of SUD in infants was conducted in Italy. Methodology/Principal Findings The reference population comprises around 3 million infants vaccinated in Italy in the study period 1999–2004 (1.5 million received hexavalent vaccines). Events of SUD in infants aged 1–23 months were identified through the death certificates. Vaccination history was retrieved from immunisation registries. Association between immunisation and death was assessed adopting a case series design focusing on the risk periods 0–1, 0–7, and 0–14 days after immunisation. Among the 604 infants who died of SUD, 244 (40%) had received at least one vaccination. Four deaths occurred within two days from vaccination with the hexavalent vaccines (RR = 1.5; 95% CI 0.6 to 4.2). The RRs for the risk periods 0–7 and 0–14 were 2.0 (95% CI 1.2 to 3.5) and 1.5 (95% CI 0.9 to 2.4). The increased risk was limited to the first dose (RR = 2.2; 95% CI 1.1 to 4.4), whereas no increase was observed for the second and third doses combined. Conclusions The RRs of SUD for any vaccines and any risk periods, even when greater than 1, were almost an order of magnitude lower than the estimates in Germany. The limited increase in RRs found in Italy appears confined to the first dose and may be partly explained by a residual uncontrolled confounding effect of age

The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Background: Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy. Methods: Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored. Results: A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays. Conclusions: IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients

Analysis of Channel Noise in Orthogonally Multiplexed QAM Systems

The paper deals with the background for the analysis and performance evaluation of orthogonally multiplexed QAM (OQAM) systems in the presence of noise, intersymbol interference and interchannel interference. The main result of the analysis is that the noise at the decision points is always stationary, regardless of the time-varying characteristics of the OQAM system. However, unless the filters are ideal (bandlimited and with a square-root Nyquist-shape) and the carriers are properly chosen, the noises of different branches are correlated even in the presence of an ideal channel. Hence a vector estimate method should be used instead of the classical scalar threshold detectors. Furthermore, the intersymbol interference and interchannel interference impulse responses have been evaluated. Again, the interesting result is that both relationships are time-invariant regardless of the system parameter

Spectral Analysis at the Output of a TWT Driven by an OFDM signal

The use of high power amplifiers, such as TWTs, at the output of an OFDM modulator is requested when the digital signal is to be transmitted over a broadcasting terrestrial channel. The spectral analysis at the output of a TWT driven by a Gaussian input is carried out and the result is applied to the case of an OFDM signal. Output correlation and spectral density are obtained using the Mahler's expansion of a Gaussian tetravariate and are then applied to a practical OFDM schem